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1. A patient with a history of neutropenia following chemotherapy develops a rapidly progressive pneumonia.
Bronchoalveolar lavage fluid reveals septate hyphae with acute angle (45-degree) branching. The MOST likely diagnosis is invasive pulmonary aspergillosis caused by:
A) Aspergillus fumigatus
B) Rhizopus species
C) Fusarium species
D) Mucor species
2. A Gram stain of anaerobic growth from a peritoneal fluid abscess reveals pleomorphic, pale-staining Gram- negative rods. The isolate grows on Bacteroides Bile Esculin (BBE) agar, hydrolyzing esculin (producing black colonies), and is resistant to kanamycin (1000 µg), vancomycin (5 µg), and colistin (10 µg) disks. Which organism group is most likely?
A) Fusobacterium nucleatum
B) Prevotella melaninogenica group
C) Bacteroides fragilis group
D) Clostridium perfringens
3. A research laboratory is investigating the mechanism of action of a novel antiviral drug against herpes simplex virus. The drug is found to inhibit the viral DNA polymerase. Which of the following commercially available antiviral agents has a similar mechanism of action?
A) Interferon-alpha
B) Oseltamivir
C) Acyclovir
D) Amantadine
4. A sputum sample from a patient with suspected pulmonary tuberculosis is submitted for AFB smear and culture. The smear is reported as positive for acid-fast bacilli (4+). Which method is considered the gold standard for confirming the identification of Mycobacterium tuberculosis complex from culture?
A) Niacin accumulation test
B) Nucleic acid amplification test (NAAT) targeting specific MTC sequences
C) HPLC analysis of mycolic acids
D) Growth rate and colony morphology on Löwenstein-Jensen media
5. A research laboratory is investigating the mechanisms of antiviral drug resistance. They are studying a herpes simplex virus strain that has developed resistance to acyclovir. The MOST common mechanism of acyclovir resistance in HSV involves mutations in the gene encoding:
A) Viral DNA polymerase
B) Viral thymidine kinase
C) Viral protease
D) Viral glycoprotein D
Solutions:
| Question # 1 Answer: A | Question # 2 Answer: C | Question # 3 Answer: C | Question # 4 Answer: B | Question # 5 Answer: B |
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